@conference {3672,
	title = {Preliminary linkage studies in sheep of keratin and keratin-associated protein genes with fleece weight, wool fibre diameter and fibre curvature},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {75},
	year = {2015},
	month = {07/2015},
	address = {Dunedin},
	abstract = { A linkage study was conducted to detect variations in the genes for keratins and keratin-associated proteins (KRTAP) that might
affect wool traits. To date 93 such genes have been identified in sheep: 85 of them (~91\%) are clustered in three chromosomal
regions. Twenty-one genes are grouped within a 4-Mbp region on sheep chromosome 1 (OAR1), 28 within a 1-Mbp segment on
chromosome 3 (OAR3), and 36 are clustered within a 1.3-Mbp site on chromosome 11 (OAR11). The DNA markers used in this
work were single nucleotide polymorphisms (SNPs) dispersed throughout these keratin and KRTAP gene clusters. Markers were
designed as three SNP-multiplexes: a 25-SNP, a 15-SNP and a 19-SNP multiplex for keratins/KRTAP regions on OAR1, OAR3
and OAR11, respectively. Resource animals came from eleven sire families whose progeny had been phenotyped for greasy fleece
weight, washing yield, fibre curvature and diameter. Between 29 and 45 progeny per sire were genotyped with the three SNPmultiplexes.
Linkage analyses on co-segregation of SNP alleles from sires with wool phenotypes of progeny were done across all
the sires and within sire groups. Based on theoretical genome-wide threshold (F-value 10.13 and nominal P = 0.0016 for withinsire
suggestive level), one family showed suggestive quantitative trait loci for greasy fleece weight on OAR1 and fibre diameter
variability on OAR3. For these experimental animals, the results show no strong evidence of involvement of keratin and KRTAP
genes in the wool characteristics analysed.},
	issn = {1176-5283},
	author = {Phua SH and Scobie DR and O{\textquoteright}Connell D and Henry H and Dodds KG and Brauning R and Clerens S}
}
@conference {60957,
	title = {Relationship between blood phylloerythrin concentration and gamma-glutamyltransferase activity in facial eczema-affected cattle and sheep},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {69},
	year = {2009},
	month = {Jun},
	pages = {118-122},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Christchurch},
	abstract = {Phylloerythrin (PLE) is a photo-dynamic compound, a natural breakdown product of chlorophyll. Its concentration and relationship with gamma-glutamyltransferase (GGT) were determined in animals seriously affected with facial eczema (FE). Seven commercial cattle herds (n = 1,455) and one experimental sheep flock (n = 597), each containing clinically affected animals, were monitored. On a pooled within-farm basis, mean PLE concentration was significantly higher in clinical FE cases than in non-clinical animals in cattle (28.7 vs 16.0 relative units, P <0.001), and in lambs (0.282 vs 0.024 {\textmu}g/ml, respectively, P <0.001). PLE concentration rose in some, but not all, animals when GGT activity exceeded \~{}600 IU/L in cattle and \~{}400 IU/L in lambs (Reference GGT range in normal (unchallenged) animals: 0 to 40 IU/L, cattle; 32 to 70 IU/L, sheep). A heritability for PLE concentration was estimated in cattle (0.19 {\textpm} 0.07), and phenotypic and genetic correlations with LogeGGT were 0.37 {\textpm} 0.02 and 0.92 {\textpm} 0.09, respectively. In the lambs the phenotypic correlation between LogeGGT and PLE was 0.32 {\textpm} 0.04. Thus PLE is a partially inherited trait, and is associated with visible signs of FE, especially above GGT thresholds of \~{}600 IU/L in cattle and \~{}400 IU/L in lambs. },
	issn = {1176-5283},
	author = {Morris CA and Hickey SM and Phua SH}
}
@conference {41719,
	title = {Current status of QTL and association studies in New Zealand cattle , sheep and deer},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {67},
	year = {2007},
	month = {Jan},
	pages = {153-159},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Wanaka},
	abstract = {In the last 15 years, a series of experiments has beencarried out to search for quantitative trait loci (QTL) in New Zealand cattle, sheepand deer. A QTL represents the position on a chromosome where there is a statistically significant genetic effecton a measured trait. This paper reviews data published so far from these QTL trials and from various association studies. Although the measurement of traits (or {\textquoteleft}phenotypes{\textquoteright}) and the sampling of tissue or fluid for DNA may be complete, the genotyping of DNA isstill incomplete in most studies; further work may be expected as new DNA genotyping techniques and new genomic data become available, and as funds allow. In cattle, we describe the current status of research for carcass composition, meat quality, pubertal traits, milk yield and milk composition traits, and resistance to facial eczema and bloat. In sheep, we include QTL searches for disease traits (resistance to nematode parasites, facial eczema, ryegrass staggers, and footrot), muscling and carcass composition, reproductive traits, wool traits, and lamb survival. In deer, QTL searches have been carried out for live weights, seasonality and pubertal traits, using measurements from an interspecific hybrid. Generally, significant results have been followed further by finemapping and independent validation, before release to industry. Some of the mapping techniques will be described, with examples. So far, QTLs under study in New Zealand have led to the identification and use of gene-tests or marker-tests for meat tenderness and carcass composition in beef cattle, milk yield and composition traits in dairy cattle, and meat yield \%, muscling and litter size genes in sheep.},
	issn = {1176-5283},
	author = {Morris CA and Campbell AW and Cullen NG and Davis GH and Everett-Hincks JM and Hall RJ and Henry HM and PL Johnson and McEwan JC and Phua SH and Wilson T}
}
