@conference {75863,
	title = {Fenbendazole as a possible marker of supplement intake in sheep},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {71},
	year = {2011},
	month = {Jan},
	pages = {13-16},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Invercargill},
	abstract = {This study aimed to determine the dose-dependent relationship between oral doses of fenbendazole (FBZ) and the plasma concentration of its metabolites, oxfendazole (OFZ) and fenbendazole-sulphone (SUL). Twenty five, two year-old, Merino wethers were equally allocated to treatment groups of different oral dose rates of FBZ (n = 5) and housed in individual pens. Treatment groups were designed to provide daily oral doses of 0.25, 0.5, 1.0, 2.0 and 4.0 mg/kg live weight of FBZ, suspended in water, for six days. Blood samples were collected from each animal at 48, 96, and 144 hours after administration of FBZ. Plasma was equally combined within each animal and analysed to determine concentrations of FBZ, OFZ and SUL. There was a positive linear relationship between FBZ dose rate and FBZ metabolite plasma concentration (R2 = 0.991, P <0.001). Mean separation of plasma concentrations indicated significant differences (P <0.05) between treatments designed to provide 1.0, 2.0 or 4.0 mg/kg/day FBZ. Plasma concentrations of animals which received 0.25 or 0.50 mg/kg/day FBZ were significantly lower than other treatments (P <0.05). The results from this experiment provide preliminary support for the investigation of FBZ as a useful marker to estimate supplement intake of grazing animals.},
	issn = {1176-5283},
	author = {Fishpool FJ and Kahn LP and Tucker DJ and Nolan JV and Leng RA}
}
@conference {41643,
	title = {Whole-body protein turnover in Merino sheep selected for wool and body growth},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {66},
	year = {2006},
	month = {Jan},
	pages = {200-205},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Napier},
	abstract = {The objective of this research was to identify metabolites produced by commensal bacteria that enhance the integrity of the gastrointestinal barrier (GIB). The integrity of the GIB is mainly determined by the complexity of interactions between tight junctions of opposing epithelial cells of the GI wall. This was measured using an in vitrobioassay, consisting of a monolayer of intestinal epithelial cells grown on a membrane. The trans-epithelial electrical resistance (TEER) across this monolayer was measured to determine the strength of the tight junctions. Preliminary results showed that a commercial probiotic product caused an increase in TEER across non-differentiated and differentiated monolayers by 178 {\textpm} 61\% and 40 {\textpm} 9\%, respectively. The maximum increases in TEER obtained with conditioned media fractions (media fractions containing components secreted by the probioticproduct) was between 23 {\textpm} 6\% and 43 {\textpm} 4\%. The conditioned media fraction containing components less than 3 kDa accounted for the total activity of the whole conditioned media. Metabolite profiling ofactive conditioned media compared to inactive conditioned media using fast-LCMSMS identified numerousmetabolites that may be responsible for this positive effect. Future work will isolate the candidate metabolites and screen them for GIB enhancing activity both in vitroand in vivo.},
	issn = {1176-5283},
	author = {Li L and Oddy VH and Godwin I and Hegarty J and Nolan JV}
}
