@conference {89268,
	title = {The effect of re-milking following extended non-milking periods on the proliferation and apoptosis of mammary gland epithelial cells in dairy cows},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {73},
	year = {2013},
	month = {Jan},
	pages = {51-53},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Hamilton},
	abstract = {<p>In dairy cows, the increase in milk yield from parturition to peak lactation is attributed to an increase in the secretory activity of mammary epithelial cells (MECs) (Capuco et al. 2001). However, following peak lactation, there is a decline in milk production, which is attributed to the loss of MECs by programmed cell death or apoptosis (Capuco et al. 2001). The role of involution and the factors that regulate it in the bovine mammary gland are not well understood. Previous studies have characterised the process of involution in the bovine mammary gland by determining whether involution is reversible following an extended milk stasis. Involution was fully reversible following seven days of non-milking (Dalley \&amp; Davis 2006), but was only partially reversible following longer non-milking intervals (Noble \&amp; Hurley 1999; Singh et al. 2012).</p>
},
	issn = {1176-5283},
	author = {Mallah GS and Dobson J and Moon S and Henderson HV and Molenaar A and Guan J and Singh K}
}
@conference {60944,
	title = {Understanding the interaction of prolactin and leukaemia inhibitory factor signalling during the switch from lactation to involution : Brief Communication},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {69},
	year = {2009},
	month = {Jun},
	pages = {65-67},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Christchurch},
	abstract = {The molecular mechanisms involved in involution of the bovine udder, a process which underpins lactation persistency, are poorly understood. During rodent lactation, STAT5 is activated in response to prolactin (PRL) to stimulate milk protein production (Liu et al., 1997). At the onset of involution, STAT5 is rapidly inactivated (Schmitt-Ney et al., 1992), and STAT3 is activated by leukaemia inhibitory factor (LIF) to... Continued},
	issn = {1176-5283},
	author = {Singh K and Vetharaniam I and Prewitz M and Dobson J and Stelwagen K}
}
@conference {41459,
	title = {Decreased gene expression of integrins in epithelial cells during mammary engorgement},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {64},
	year = {2004},
	month = {Jan},
	pages = {11-13},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Hamilton},
	abstract = {In ruminants, the molecular mechanisms regulating mammary involution and apoptosis (programmed cell death) are not well characterised, but extensive research in rodents has established that many cell types, including mammary epithelial cells, require anchorage to the extracellular matrix for survival. This anchorage is mediated via the integrins, a family of transmembrane glycoproteins that bridge intra- and extracellular compartments enabling direct communication between adaptor molecules in the cytoplasm and specific receptor motifs on the ECM proteins (Clark \& Brugge, 1995; Giancotti \& Ruoslahti, 1999; Hynes, 1992).  Integrins form heterodimers between α and β subunits to produce more than 20 different receptors, and many subtypes have been identified in mammary glands (Clark \& Brugge, 1995).  We have shown previously that one such integrin, β1, is reduced rapidly as a result of induced weaning in rodents, and these changes are followed by apoptosis (McMahon et al., 2004).  The aim of this study was to investigate the molecular mechanisms that may regulate mammary involution in the bovine by examining cell-matrix interactions that may be involved in survival of mammary epithelial cells, ultimately to improve lactational persistency and tolerance of extended milking intervals ... },
	issn = {1176-5283},
	author = {Singh K and Dobson J and Stelwagen K and Prosser CG and Farr VC and Molenaar A and Davis SR}
}
