@conference {40561,
	title = {A prolonged change in body composition induced by endocrine manipulation of the neonate},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {54},
	year = {1994},
	month = {Jan},
	pages = {51-54},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {The ability of endocrine manipulation of the neonate to effect prolonged  
changes in body composition was examined.  Treatment of lambs with  
recombinant bovine somatotropin (rbST) at doses of 0.1 or 0.3 mg/kg  
liveweight/day for 11 weeks from birth elevated circulating ST concentrations  
(P<0.01) but had no effect on circulating concentrations of insulin-like growth  
factor-1 or on liveweight gain compared with excipient-treated lambs.   
However, at 8 months of age (5 months after cessation of treatment),  
ultrasound backfat depths (Mean{\textpm}SE) were significantly (P<0.05) higher in  
lambs previously treated with excipient (3.4{\textpm}0.3 mm) than in those treated with  
rbST at 0.1 mg/kg (2.8{\textpm}0.3 mm) or 0.3 mg/kg (2.5{\textpm}0.3 mm).  In a second  
study, rats were treated with saline vs. 0.2 ug/g rbST vs. 0.4 ug/g rbST vs. 0.2  
ug/g pituitary ovine prolactin (poPRL) vs. 0.4 mu/g poPRL for the first 21 days  
of life.  At 120 days of age they were euthanased, selected fat depots weighed  
and the carcasses analysed for fat content.  Neonatal treatment with rbST or  
poPRL significantly (P<0.05) reduced weight of the subcutaneous scapular fat  
depot (1.08{\textpm}0.18 vs. 0.46{\textpm}0.17 vs. 0.52{\textpm}0.18 vs. 0.50{\textpm}0.17 vs. 0.49{\textpm}0.17 g)  
and carcass fat content (5.88{\textpm}0.27 vs. 5.03{\textpm}0.26 vs. 4.58{\textpm}0.27 vs. 5.28{\textpm}0.26  
vs. 4.70{\textpm}0.26\%) but did not influence weights of the subcutaneous abdominal,  
genital or perirenal fat depots.  These results suggest that endocrine  
manipulation of the neonate may offer a means of producing desirable changes  
in the composition of production animals while avoiding consumer resistance  
to the use of hormonal growth promotants close to the time of slaughter. },
	issn = {1176-5283},
	author = {McCutcheon SN and Kadim IT and Wickham GA and Purchas RW}
}
